|
Post by skytroll on Sept 4, 2007 13:49:13 GMT -5
Scientists starting to self-destruct, Pharma included........The lies are surfacing. Unproven meds: snippet: "crucial feature of the mutant ErbB1 receptors, Hendriks found, was that they couldn't shut down like normal receptors. Normally, cells downregulate the replication pathway by yanking their receptors inside the cell wall, but the ErbB1 mutants appeared to have trouble internalizing. To test this theory, the team labeled normal and mutant receptors in vitro after saturating them with the epidermal growth factor. The mutants glowed,4 and the mystery was solved: The diagnostic feature of responders wasn't the mutation, it was the internalization rates. Iressa was only good at disabling those reluctant receptors hanging outside of cells. A computational systems biology program was up and running at AstraZeneca. The company's success at finding out why Iressa didn't work did not go unnoticed at other companies, many of which are gradually building their multidisciplinary departments to achieve the pharmaceutical Holy Grail: Rational drug design using a full systems-based knowledge of biology. AstraZeneca's approach to Iressa "helped systems biology get accepted in the whole industry, not just [at] AstraZeneca," says computational biologist Bruce Gomes, head of systems biology at Pfizer. "............ www.the-scientist.com/article/home/53421/SKytroll
|
|
|
Post by skytroll on Sept 4, 2007 14:13:36 GMT -5
|
|
|
Post by skytroll on Sept 4, 2007 14:14:56 GMT -5
|
|
|
Post by skytroll on Sept 4, 2007 14:17:57 GMT -5
|
|
|
Post by skytroll on Sept 4, 2007 14:25:39 GMT -5
September 02, 2007 Structural Studies Reveal New Clues to Prion Infectivity
" research team led by Howard Hughes Medical Institute investigator Jonathan S. Weissman analyzed the structures of two unmodified yeast Sup35 prion proteins in two infectious conformations. They identified key structural differences that explain the different behaviors of these prions. The researchers published their findings online September 2, 2007, in the journal Nature. Weissman and his colleagues are at the University of California, San Francisco. "
I tell you follow that SUP 35.......
Weissman, at Alta summit 1984?
"We now appreciate that the same polypeptide can misfold into dramatically different conformations. These different conformations can lead to dramatic changes in the structure of the prion form. This difference in structure, in turn, can change the physical properties of prions, which can affect their ability to propagate.”
Ultimately Weissman hopes a better understanding of prion misfolding will lead to therapeutic approaches to diseases caused by misfolded proteins.
“We know that some protein conformations—not only for prion diseases but for the far more common diseases of misfolding like Alzheimer's and Parkinson's—seem to be very toxic, whereas others seem to be relatively neutral or even protective,” he said. “We would like to understand the structural basis for the difference between the infectious, toxic or dangerous forms of misfolded proteins, and the neutral or protective forms. And then ultimately, we could try to develop therapies in which we push proteins down the pathways of the less pathogenic or less dangerous conformations.”
What a scurrying to cover the evidence. But, the evidence is proving itself..........
SKytroll
|
|
|
Post by skytroll on Sept 4, 2007 19:39:48 GMT -5
Good fit boonie.
Skytroll
|
|
|
Post by skytroll on Sept 5, 2007 12:56:36 GMT -5
New wisdom: or tracking devices? and cancer causing cell phones? Listening for Ads Research firm IMMI tracks ad exposure by sampling sound through cell phones. www.technologyreview.com/Biztech/19336/Just 10 Minutes Of Cellphone Chat May Trigger Cancer - Weizmann Institute www.chinadaily.com.cn/lifestyle/2007-09/04/content_6079922.htm Just 10 minutes of cellphone chat may trigger cancer (ANI) Updated: 2007-09-04 15:29 Just 10 minutes of chatting on cellular phones is enough to trigger such chemical changes in the brain that can increase the risk of cancer, warn scientists. A study by the Weizmann Institute of Science in Israel has shown that even low levels of radiation from handsets interfere with the process of cell division, which encourages the growth of tumors. Although the researchers have yet not found any evidence that signals from cell phones are harmful, their findings suggest they may be. Several studies have been conducted to find an association between mobile use and brain tumours, but they neither found any such link nor any dramatic rise in cancer rates. Ever since the inception of mobile phones, the official advice has been that the device are safe. The guidance is based on the assumption that the phones emit too little radiation to heat the brain dangerously. The new study, however, suggests that "nonthermal" radiation can pose a risk. In lab tests, the researchers exposed human and rat cells to low-level radiation at 875 megahertz, a similar frequency to the one used in many mobile phones. Despite being weaker than emissions from a typical handset, the radiation began to switch on a chemical signal inside the cells within ten minutes, say the researchers. The chemical signals detected were involved in the division of cells, they add. The researchers also claimed to have found a separate way in which mobile phones can damage health. "The significance lies in showing cells do react to cellphone radiation in a non-thermal way," the Daily Mail quoted Dr Rony Seger, a co-author of the study published in the Biochemical Journal, as telling New Scientist magazine. <snipt> -------------------------------------------------------------------------------- Skytroll
|
|