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Detection of tick-borne infection in Morgellons disease patients by serological and molecular techniques
by serological and molecular techniques
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Authors Middelveen MJ, Du Cruz I, Fesler MC, Stricker RB, Shah JS
Received 19 August 2018
Accepted for publication 3 October 2018
Published 9 November 2018 Volume 2018:11 Pages 561—569
DOI doi.org/10.2147/CCID.S184521
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 3
Editor who approved publication: Dr Jeffrey Weinberg
Article has an altmetric score of 144
Video abstract presented by Melissa C Fesler.
Views: 14499
Marianne J Middelveen,1 Iris Du Cruz,2 Melissa C Fesler,3 Raphael B Stricker,3 Jyotsna S Shah2
1Atkins Veterinary Services, Calgary, AB, Canada; 2IGeneX Laboratories, Palo Alto, CA, USA; 3Union Square Medical Associates, San Francisco, CA, USA
Background: Morgellons disease (MD) is a skin condition associated with Lyme disease (LD) and tick-borne illness. Patients with this skin disorder experience ulcerative lesions that contain multicolored filamentous collagen and keratin inclusions. Infection with various species of Borrelia and other tick-borne pathogens has been detected in tissue and body fluid specimens from MD patients. We sought to explore this association further in a cohort of MD patients.
Patients and methods: Sera from 30 patients with MD were tested for antibody reactivity to antigens from the Borrelia burgdorferi (Bb) group and the relapsing fever Borrelia (RFB) group of spirochetes. Tissue and/or body fluid specimens from these patients were also tested for the presence of Bb and RFB infection using PCR technology. In addition, tissue and body fluid specimens were tested for the presence of Bartonella henselae using PCR, and formalin-fixed skin sections from a subset of patients were tested using fluorescent in situ hybridization (FISH) with B. henselae-specific DNA probes.
More at this link: www.dovepress.com/detection-of-tick-borne-infection-in-morgellons-disease-patients-by-se-peer-reviewed-article-CCID?
-----------------------------
Many Blessings,
CrystalRiver
Detection of tick-borne infection in Morgellons disease patients by serological and molecular techniques
by serological and molecular techniques
Abstract
Fulltext
Metrics
Get Permission
Cite this article
Authors Middelveen MJ, Du Cruz I, Fesler MC, Stricker RB, Shah JS
Received 19 August 2018
Accepted for publication 3 October 2018
Published 9 November 2018 Volume 2018:11 Pages 561—569
DOI doi.org/10.2147/CCID.S184521
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 3
Editor who approved publication: Dr Jeffrey Weinberg
Article has an altmetric score of 144
Video abstract presented by Melissa C Fesler.
Views: 14499
Marianne J Middelveen,1 Iris Du Cruz,2 Melissa C Fesler,3 Raphael B Stricker,3 Jyotsna S Shah2
1Atkins Veterinary Services, Calgary, AB, Canada; 2IGeneX Laboratories, Palo Alto, CA, USA; 3Union Square Medical Associates, San Francisco, CA, USA
Background: Morgellons disease (MD) is a skin condition associated with Lyme disease (LD) and tick-borne illness. Patients with this skin disorder experience ulcerative lesions that contain multicolored filamentous collagen and keratin inclusions. Infection with various species of Borrelia and other tick-borne pathogens has been detected in tissue and body fluid specimens from MD patients. We sought to explore this association further in a cohort of MD patients.
Patients and methods: Sera from 30 patients with MD were tested for antibody reactivity to antigens from the Borrelia burgdorferi (Bb) group and the relapsing fever Borrelia (RFB) group of spirochetes. Tissue and/or body fluid specimens from these patients were also tested for the presence of Bb and RFB infection using PCR technology. In addition, tissue and body fluid specimens were tested for the presence of Bartonella henselae using PCR, and formalin-fixed skin sections from a subset of patients were tested using fluorescent in situ hybridization (FISH) with B. henselae-specific DNA probes.
More at this link: www.dovepress.com/detection-of-tick-borne-infection-in-morgellons-disease-patients-by-se-peer-reviewed-article-CCID?
-----------------------------
Many Blessings,
CrystalRiver