Post by whiterose on Oct 18, 2007 8:29:45 GMT -5
Drug-Induced Diseases
www.worstpills.org/public/page.cfm?op_id=5
How Extensive Is the Problem of Specific Adverse Drug Reactions?
Specific Examples of Patients with Drug-Induced Diseases
Summary of Adverse Reactions and the Drugs that Cause Them
How Extensive Is the Problem of Specific Adverse Drug Reactions?
Each year, more than 9.6 million adverse drug reactions occur in older Americans. One study found that 37 percent of adverse reactions in the elderly were not reported to the doctor, presumably because patients did not realize the reactions were due to the drug. This is not too surprising considering that most doctors admitted they did not explain possible adverse effects to their patients.1
We based the following national estimates on well-conducted studies, mainly in the United States:
Each year, in hospitals alone, there are 28,000 cases of life-threatening heart toxicity from adverse reactions to digoxin, the most commonly used form of digitalis (drugs that regulate the speed and strength of heart beats) in older adults.2 Since as many as 40% or more of these people are using this drug unnecessarily (see discussion on digoxin), many of these injuries are preventable.
Each year 41,000 older adults are hospitalized—and 3,300 of these die—from ulcers caused by NSAIDs (nonsteroidal anti-inflammatory drugs, usually for treatment of arthritis).3 Thousands of younger adults are hospitalized. (See list of drugs that can cause gastrointestinal bleeding.)
At least 16,000 injuries from auto crashes each year involving older drivers are attributable to the use of psychoactive drugs, specifically benzodiazepines and tricyclic antidepressants.4 Psychoactive drugs are those that affect the mind or behavior. (See list of drugs that can cause automobile accidents.)
Each year 32,000 older adults suffer from hip fractures attributable to drug-induced falls, resulting in more than 1,500 deaths.5, 6 In one study, the main categories of drugs responsible for the falls leading to hip fractures were sleeping pills and minor tranquilizers (30%), antipsychotic drugs (52%), and antidepressants (17%). All of these categories of drugs are often prescribed unnecessarily, especially in older adults. (See section on sleeping pills and tranquilizers, antipsychotic drugs, and antidepressants; see also list of drugs that can cause hip fractures because of drug-induced falls.)
Approximately 163,000 older Americans suffer from serious mental impairment (memory loss, dementia) either caused or worsened by drugs.7, 8 In a study in the state of Washington, in 46% of the patients with drug-induced mental impairment, the problem was caused by minor tranquilizers or sleeping pills; in 14%, by high blood pressure drugs; and in 11%, by antipsychotic drugs. (See list of drugs that can cause or worsen dementia.)
Two million older Americans are addicted or at risk of addiction to minor tranquilizers or sleeping pills because they have used them daily for at least one year, even though there is no acceptable evidence that the tranquilizers are effective for more than four months, and the sleeping pills for more than 30 days.9
Drug-induced tardive dyskinesia has developed in 73,000 older adults; this condition is the most serious and common adverse reaction to antipsychotic drugs, and it is often irreversible. Tardive dyskinesia is characterized by involuntary movements of the face, arms and legs. About 80% of older adults receiving antipsychotic drugs do not have schizophrenia or other conditions that justify the use of such powerful drugs, so many of these patients have serious side effects from drugs that were prescribed inappropriately.10 (See list of drugs that can cause tardive dyskinesia or other movement disorders.)
Drug-induced parkinsonism has developed in 61,000 older adults also due to the use of antipsychotic drugs such as haloperidol (HALDOL), chlorpromazine (THORAZINE), thioridazine (MELLARIL), trifluoperazine (STELAZINE), and fluphenazine (PROLIXIN). There are other parkinsonism-inducing drugs as well, such as metoclopramide (REGLAN), prochlorperazine (COMPAZINE), and promethazine (PHENERGAN), prescribed for gastrointestinal problems.11 (See list of drugs that can cause parkinsonism.)
A serious problem exists because both doctors and patients do not realize that practically any symptom in older adults and in many younger adults can be caused or worsened by drugs.12 Some doctors and patients assume that what are actually adverse drug reactions are simply signs of aging. As a result, many serious adverse reactions are entirely overlooked or not recognized until they have caused significant harm.
The drugs responsible for the most serious adverse reactions in older adults are tranquilizers, sleeping pills, and other mind-affecting drugs; cardiovascular drugs such as high blood pressure drugs, digoxin, and drugs for abnormal heart rhythms;13 and drugs for treating intestinal problems.
Mental Adverse Drug Reactions: depression, hallucinations, confusion, delirium, memory loss, impaired thinking
Nervous System Adverse Drug Reactions: parkinsonism, involuntary movements of the face, arms, legs (tardive dyskinesia), sexual dysfunction
Gastrointestinal Adverse Drug Reactions: loss of appetite, constipation
Urinary Problems: difficulty urinating, leaking of urine
Dizziness on Standing
Falls Sometimes Resulting in Hip Fractures
Automobile Accidents Resulting in Injury
Specific Examples of Patients with Drug-Induced Diseases
Woman homebound due to a misprescribed heart drug
Liz, a 54-year old woman, was prescribed the heart drug amiodarone (CORDARONE) to treat a common heart condition. She was not told that the drug was not approved by the FDA for her condition. The pharmacy leaflet mentioned nausea and dizziness as side effects, but not lung toxicity. She is now dependent on an oxygen tank to breathe and does not have the strength to clean her house.
Man develops parkinsonism from antipsychotics prescribed for “irritable bowel syndrome”
Larry was an otherwise healthy 58-year-old man with diarrhea believed to be due to “irritable bowel syndrome.” He was given trifluoperazine (STELAZINE), a powerful antipsychotic, to “calm down” his intestinal tract. STELAZINE is not even approved for treating such medical problems. Six months after starting STELAZINE, Larry developed severe parkinsonism, a neurological condition characterized by tremor, limited movements, rigidity and postural instability. To correct this, Larry was started on L-dopa (also known as levodopa), a drug to treat Parkinson’s disease. Presumably, the doctor did not realize the parkinsonism was drug-induced, and the STELAZINE was continued. For seven years, Larry took both drugs until seeing a Parkinson’s specialist. The specialist recognized the real cause of his problem, stopped the STELAZINE, and slowly withdrew the L-dopa over a six-month period. Larry’s severe, disabling parkinsonism cleared completely. <snit>
www.worstpills.org/public/page.cfm?op_id=5
How Extensive Is the Problem of Specific Adverse Drug Reactions?
Specific Examples of Patients with Drug-Induced Diseases
Summary of Adverse Reactions and the Drugs that Cause Them
How Extensive Is the Problem of Specific Adverse Drug Reactions?
Each year, more than 9.6 million adverse drug reactions occur in older Americans. One study found that 37 percent of adverse reactions in the elderly were not reported to the doctor, presumably because patients did not realize the reactions were due to the drug. This is not too surprising considering that most doctors admitted they did not explain possible adverse effects to their patients.1
We based the following national estimates on well-conducted studies, mainly in the United States:
Each year, in hospitals alone, there are 28,000 cases of life-threatening heart toxicity from adverse reactions to digoxin, the most commonly used form of digitalis (drugs that regulate the speed and strength of heart beats) in older adults.2 Since as many as 40% or more of these people are using this drug unnecessarily (see discussion on digoxin), many of these injuries are preventable.
Each year 41,000 older adults are hospitalized—and 3,300 of these die—from ulcers caused by NSAIDs (nonsteroidal anti-inflammatory drugs, usually for treatment of arthritis).3 Thousands of younger adults are hospitalized. (See list of drugs that can cause gastrointestinal bleeding.)
At least 16,000 injuries from auto crashes each year involving older drivers are attributable to the use of psychoactive drugs, specifically benzodiazepines and tricyclic antidepressants.4 Psychoactive drugs are those that affect the mind or behavior. (See list of drugs that can cause automobile accidents.)
Each year 32,000 older adults suffer from hip fractures attributable to drug-induced falls, resulting in more than 1,500 deaths.5, 6 In one study, the main categories of drugs responsible for the falls leading to hip fractures were sleeping pills and minor tranquilizers (30%), antipsychotic drugs (52%), and antidepressants (17%). All of these categories of drugs are often prescribed unnecessarily, especially in older adults. (See section on sleeping pills and tranquilizers, antipsychotic drugs, and antidepressants; see also list of drugs that can cause hip fractures because of drug-induced falls.)
Approximately 163,000 older Americans suffer from serious mental impairment (memory loss, dementia) either caused or worsened by drugs.7, 8 In a study in the state of Washington, in 46% of the patients with drug-induced mental impairment, the problem was caused by minor tranquilizers or sleeping pills; in 14%, by high blood pressure drugs; and in 11%, by antipsychotic drugs. (See list of drugs that can cause or worsen dementia.)
Two million older Americans are addicted or at risk of addiction to minor tranquilizers or sleeping pills because they have used them daily for at least one year, even though there is no acceptable evidence that the tranquilizers are effective for more than four months, and the sleeping pills for more than 30 days.9
Drug-induced tardive dyskinesia has developed in 73,000 older adults; this condition is the most serious and common adverse reaction to antipsychotic drugs, and it is often irreversible. Tardive dyskinesia is characterized by involuntary movements of the face, arms and legs. About 80% of older adults receiving antipsychotic drugs do not have schizophrenia or other conditions that justify the use of such powerful drugs, so many of these patients have serious side effects from drugs that were prescribed inappropriately.10 (See list of drugs that can cause tardive dyskinesia or other movement disorders.)
Drug-induced parkinsonism has developed in 61,000 older adults also due to the use of antipsychotic drugs such as haloperidol (HALDOL), chlorpromazine (THORAZINE), thioridazine (MELLARIL), trifluoperazine (STELAZINE), and fluphenazine (PROLIXIN). There are other parkinsonism-inducing drugs as well, such as metoclopramide (REGLAN), prochlorperazine (COMPAZINE), and promethazine (PHENERGAN), prescribed for gastrointestinal problems.11 (See list of drugs that can cause parkinsonism.)
A serious problem exists because both doctors and patients do not realize that practically any symptom in older adults and in many younger adults can be caused or worsened by drugs.12 Some doctors and patients assume that what are actually adverse drug reactions are simply signs of aging. As a result, many serious adverse reactions are entirely overlooked or not recognized until they have caused significant harm.
The drugs responsible for the most serious adverse reactions in older adults are tranquilizers, sleeping pills, and other mind-affecting drugs; cardiovascular drugs such as high blood pressure drugs, digoxin, and drugs for abnormal heart rhythms;13 and drugs for treating intestinal problems.
Mental Adverse Drug Reactions: depression, hallucinations, confusion, delirium, memory loss, impaired thinking
Nervous System Adverse Drug Reactions: parkinsonism, involuntary movements of the face, arms, legs (tardive dyskinesia), sexual dysfunction
Gastrointestinal Adverse Drug Reactions: loss of appetite, constipation
Urinary Problems: difficulty urinating, leaking of urine
Dizziness on Standing
Falls Sometimes Resulting in Hip Fractures
Automobile Accidents Resulting in Injury
Specific Examples of Patients with Drug-Induced Diseases
Woman homebound due to a misprescribed heart drug
Liz, a 54-year old woman, was prescribed the heart drug amiodarone (CORDARONE) to treat a common heart condition. She was not told that the drug was not approved by the FDA for her condition. The pharmacy leaflet mentioned nausea and dizziness as side effects, but not lung toxicity. She is now dependent on an oxygen tank to breathe and does not have the strength to clean her house.
Man develops parkinsonism from antipsychotics prescribed for “irritable bowel syndrome”
Larry was an otherwise healthy 58-year-old man with diarrhea believed to be due to “irritable bowel syndrome.” He was given trifluoperazine (STELAZINE), a powerful antipsychotic, to “calm down” his intestinal tract. STELAZINE is not even approved for treating such medical problems. Six months after starting STELAZINE, Larry developed severe parkinsonism, a neurological condition characterized by tremor, limited movements, rigidity and postural instability. To correct this, Larry was started on L-dopa (also known as levodopa), a drug to treat Parkinson’s disease. Presumably, the doctor did not realize the parkinsonism was drug-induced, and the STELAZINE was continued. For seven years, Larry took both drugs until seeing a Parkinson’s specialist. The specialist recognized the real cause of his problem, stopped the STELAZINE, and slowly withdrew the L-dopa over a six-month period. Larry’s severe, disabling parkinsonism cleared completely. <snit>