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Post by whiterose on Feb 13, 2007 22:23:57 GMT -5
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Post by whiterose on Mar 17, 2007 16:10:59 GMT -5
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Post by skytroll on Mar 17, 2007 22:21:09 GMT -5
Quantum dots and nanobots? nanoparticle enzymes. content.febsjournal.org/cgi/content/abstract/274/2/302O my G.........this could be the study my son's doc mentioned to us. And it involves AMYLOID FIBRILS. and Pancreatitis. AMYLOID FIBERS LIKE PRIONS? ......"Human pancreatitis-associated protein was identified in pathognomonic lesions of Alzheimer disease, a disease characterized by the presence of filamentous protein aggregates. Here, we showed that at physiological pH, human pancreatitis-associated protein forms non-Congo Red-binding, proteinase K-resistant fibrillar aggregates with diameters from 6 up to as large as 68 nm. Interestingly, circular dichroism and Fourier transform infrared spectra showed that, unlike typical amyloid fibrils, which have a cross--sheet structure, these aggregates have a very similar secondary structure to that of the native protein, which is composed of two -helices and eight -strands, as determined by NMR techniques. Surface structure analysis showed that the positively charged and negatively charged residues were clustered on opposite sides, and strong electrostatic interactions between molecules were therefore very likely, which was confirmed by cross-linking experiments. In addition, several hydrophobic residues were found to constitute a continuous hydrophobic surface. These results and protein aggregation prediction using the TANGO algorithm led us to synthesize peptide Thr84 to Ser116, which, very interestingly, was found to form amyloid-like fibrils with a cross- structure. Thus, our data suggested that human pancreatitis-associated protein fibrillization is initiated by protein aggregation primarily because of electrostatic interactions, and the loop from residues 84 to 116 may play an important role in the formation of fibrillar aggregates with a native-like conformation"www.jbc.org/cgi/content/abstract/281/44/33566NOTICE: ELECTROSTATIC INTERACTIONS and residues could be the sludge, also the first doc said that there was particulate matter in the ducts. I wonder if the electrostatic fibers wrap around the ducts causing the closings? Electrostatic/bio connection next. skytroll
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Post by whiterose on Mar 18, 2007 2:27:33 GMT -5
I'd guess you hit the nail on the head with that one skytroll.
When I first got this and I felt it squeeze my arm muscle, I knew if that thing wanted to it could give me a heart attack, I'm sure it has to others, especially men, just an educated guess after all the research I've done.
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