Post by Admin on Sept 16, 2015 14:52:18 GMT -5
www.rumormillnews.com/cgi-bin/forum.cgi?read=27835
Article on Lyme Disease Includes 'Shame Treatment'
Posted By: CrystalRiver [Send E-Mail]
Date: Wednesday, 16-Sep-2015 15:37:21
Dear RM Agents and Readers,
Looking over some recently posted information at the Charles E Holman site and came across a newly posted article as sited below
from this page:
www.ncbi.nlm.nih.gov/pubmed/26295288
Send to:
Bosn J Basic Med Sci. 2015 Jul 8;15(3):1-13. doi: 10.17305/bjbms.2015.594.
Lyme Borreliosis: Is there a preexisting (natural) variation in antimicrobial susceptibility among Borrelia burgdorferi strains?
Hodzic E1.
Author information
Abstract
The development of antibiotics changed the world of medicine and has saved countless human and animal lives. Bacterial resistance/tolerance to antibiotics have spread silently across the world and has emerged as a major public health concern. The recent emergence of pan-resistant bacteria can overcome virtually any antibiotic and poses a major problem for their successful control. Selection for antibiotic resistance may take place where an antibiotic is present: in the skin, gut, and other tissues of humans and animals and in the environment. Borrelia burgdorferi, the etiological agents of Lyme borreliosis, evades host immunity and establishes persistent infections in its mammalian hosts. The persistent infection poses a challenge to the effective antibiotic treatment, as demonstrated in various animal models. An increasingly heterogeneous subpopulation of replicatively attenuated spirochetes arises following treatment, and these persistent antimicrobial tolerant/resistant spirochetes are non-cultivable. The non-cultivable spirochetes resurge in multiple tissues at 12 months after treatment, with B. burgdorferi-specific DNA copy levels nearly equivalent to those found in shame-treated experimental animals. These attenuated spirochetes remain viable, but divide slowly, thereby being tolerant to antibiotics. Despite the continued non-cultivable state, RNA transcription of multiple B. burgdorferi genes was detected in host tissues, spirochetes were acquired by xenodiagnostic ticks, and spirochetal forms could be visualized within ticks and mouse tissues. A number of host cytokines were up- or down-regulated in tissues of both shame- and antibiotic-treated mice in the absence of histopathology, indicating a lack of host response to the presence of antimicrobial tolerant/resistant spirochetes.
PMID: 26295288 [PubMed - in process]
Is there someone from the medical community that can tell me what this means as the only thing I keep coming up with no matter where I look is that they are telling the mouse to get up out of bed you aren't really ill?
Please let me know what I've missed in this regard as I have looked for over an hour to find something different in this regard. The snip below is from the article above:
. The non-cultivable spirochetes resurge in multiple tissues at 12 months after treatment, with B. burgdorferi-specific DNA copy levels nearly equivalent to those found
in shame-treated experimental animals.
These attenuated spirochetes remain viable, but divide slowly, thereby being tolerant to antibiotics.
Many Blessings,
CrystalRiver
Article on Lyme Disease Includes 'Shame Treatment'
Posted By: CrystalRiver [Send E-Mail]
Date: Wednesday, 16-Sep-2015 15:37:21
Dear RM Agents and Readers,
Looking over some recently posted information at the Charles E Holman site and came across a newly posted article as sited below
from this page:
www.ncbi.nlm.nih.gov/pubmed/26295288
Send to:
Bosn J Basic Med Sci. 2015 Jul 8;15(3):1-13. doi: 10.17305/bjbms.2015.594.
Lyme Borreliosis: Is there a preexisting (natural) variation in antimicrobial susceptibility among Borrelia burgdorferi strains?
Hodzic E1.
Author information
Abstract
The development of antibiotics changed the world of medicine and has saved countless human and animal lives. Bacterial resistance/tolerance to antibiotics have spread silently across the world and has emerged as a major public health concern. The recent emergence of pan-resistant bacteria can overcome virtually any antibiotic and poses a major problem for their successful control. Selection for antibiotic resistance may take place where an antibiotic is present: in the skin, gut, and other tissues of humans and animals and in the environment. Borrelia burgdorferi, the etiological agents of Lyme borreliosis, evades host immunity and establishes persistent infections in its mammalian hosts. The persistent infection poses a challenge to the effective antibiotic treatment, as demonstrated in various animal models. An increasingly heterogeneous subpopulation of replicatively attenuated spirochetes arises following treatment, and these persistent antimicrobial tolerant/resistant spirochetes are non-cultivable. The non-cultivable spirochetes resurge in multiple tissues at 12 months after treatment, with B. burgdorferi-specific DNA copy levels nearly equivalent to those found in shame-treated experimental animals. These attenuated spirochetes remain viable, but divide slowly, thereby being tolerant to antibiotics. Despite the continued non-cultivable state, RNA transcription of multiple B. burgdorferi genes was detected in host tissues, spirochetes were acquired by xenodiagnostic ticks, and spirochetal forms could be visualized within ticks and mouse tissues. A number of host cytokines were up- or down-regulated in tissues of both shame- and antibiotic-treated mice in the absence of histopathology, indicating a lack of host response to the presence of antimicrobial tolerant/resistant spirochetes.
PMID: 26295288 [PubMed - in process]
Is there someone from the medical community that can tell me what this means as the only thing I keep coming up with no matter where I look is that they are telling the mouse to get up out of bed you aren't really ill?
Please let me know what I've missed in this regard as I have looked for over an hour to find something different in this regard. The snip below is from the article above:
. The non-cultivable spirochetes resurge in multiple tissues at 12 months after treatment, with B. burgdorferi-specific DNA copy levels nearly equivalent to those found
in shame-treated experimental animals.
These attenuated spirochetes remain viable, but divide slowly, thereby being tolerant to antibiotics.
Many Blessings,
CrystalRiver