Post by Admin on Apr 29, 2012 13:02:55 GMT -5
I found that they were playing with this agent at Dugway Proving Ground ---Hi Level lab in Utah---much information at this site:
www.project-112shad-fdn.com/index.htm#Battelle
www.project-112shad-fdn.com/content12.htm
Note: They were dumping from this area in the sewage plant behind my home---why you ask. Because for a few years they had set off alarms and rather than stop they just continued and altered where they rid themselves of product.
It was at one of the pages above where I came across this chemical that is listed below.
www.mendeley.com/research/effect-of-soman-pinacolyl-methylphosphonofluoridate-on-the-blood-levels-of-corticosterone-and-adrenocorticotropin-in-mice/
Abstract
Mice were poisoned by an extremely toxic organophosphate anticholinesterase soman (pinacolyl methylphosphonofluoridate), 50 or 100 micrograms/kg at 1000, and the serum concentrations of corticosterone were determined fluorometrically at 3-h intervals for at least 24 h. The lower soman dose (50 micrograms/kg) produced a modest increase in serum corticosterone concentrations but by 24 h the levels were not significantly different from control. Following the higher soman dose (100 micrograms/kg) the serum corticosterone levels were elevated significantly (p less than 0.05), for at least 27 h. However, ACTH concentrations were not elevated. It is possible that the elevated levels of corticosterone were due to a reduced metabolism and excretion of corticosterone resulting from the intense hypothermia, following soman poisoning which may change cardiac output and organ (liver and kidney) perfusion and not due to an enhanced release from the adrenal gland
Author-supplied keywords
adrenocorticotropic hormoneanimalsbloodcardiac outputcorticosteronehypothermiakidneylivermalemetabolismmiceperfusionpoisoningsoman
Related research
Effect of poisoning by soman (pinacolyl methylphosphonofluoridate) on the serum half-life of the cholinesterase reactivator HI-6 in mice.
J G Clement, K J Simons, C J Briggsin Biopharmaceutics drug disposition(1988)
Save reference to library·Related research1 reader
Sodium pentobarbital alteration of the toxicity and distribution of soman (pinacolyl methylphosphonofluoridate) in mice
J G Clementin BiochemPharmacol(1984)
Save reference to library·Related research1 reader
Importance of aliesterase as a detoxification mechanism for soman (Pinacolyl methylphosphonofluoridate) in mice.
J G Clementin Biochemical Pharmacology(1984)
Save reference to library·Related research1 reader
Effects of soman (pinacolyl methylphosphonofluoridate) on coronary blood flow and cardiac function in swine.
J E McKenzie, D M Scandling, N W Ahle, H J Bryant, R R Kyle, P H Abbrechtin Fundamental and applied toxicology official journal of the Society of Toxicology(1996)
Save reference to library·Related research2 readers
Effects of the acetylcholinesterase inhibitor pinacolyl methylphosphonofluoridate (soman) on selected endocrine, glucose, and catecholamine levels in fasted and fed rats.
H P Fletcher, S A Noble, G R Sprattoin Toxicology(1988)
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More related papers
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www.project-112shad-fdn.com/index.htm#Battelle
www.project-112shad-fdn.com/content12.htm
Note: They were dumping from this area in the sewage plant behind my home---why you ask. Because for a few years they had set off alarms and rather than stop they just continued and altered where they rid themselves of product.
It was at one of the pages above where I came across this chemical that is listed below.
www.mendeley.com/research/effect-of-soman-pinacolyl-methylphosphonofluoridate-on-the-blood-levels-of-corticosterone-and-adrenocorticotropin-in-mice/
Abstract
Mice were poisoned by an extremely toxic organophosphate anticholinesterase soman (pinacolyl methylphosphonofluoridate), 50 or 100 micrograms/kg at 1000, and the serum concentrations of corticosterone were determined fluorometrically at 3-h intervals for at least 24 h. The lower soman dose (50 micrograms/kg) produced a modest increase in serum corticosterone concentrations but by 24 h the levels were not significantly different from control. Following the higher soman dose (100 micrograms/kg) the serum corticosterone levels were elevated significantly (p less than 0.05), for at least 27 h. However, ACTH concentrations were not elevated. It is possible that the elevated levels of corticosterone were due to a reduced metabolism and excretion of corticosterone resulting from the intense hypothermia, following soman poisoning which may change cardiac output and organ (liver and kidney) perfusion and not due to an enhanced release from the adrenal gland
Author-supplied keywords
adrenocorticotropic hormoneanimalsbloodcardiac outputcorticosteronehypothermiakidneylivermalemetabolismmiceperfusionpoisoningsoman
Related research
Effect of poisoning by soman (pinacolyl methylphosphonofluoridate) on the serum half-life of the cholinesterase reactivator HI-6 in mice.
J G Clement, K J Simons, C J Briggsin Biopharmaceutics drug disposition(1988)
Save reference to library·Related research1 reader
Sodium pentobarbital alteration of the toxicity and distribution of soman (pinacolyl methylphosphonofluoridate) in mice
J G Clementin BiochemPharmacol(1984)
Save reference to library·Related research1 reader
Importance of aliesterase as a detoxification mechanism for soman (Pinacolyl methylphosphonofluoridate) in mice.
J G Clementin Biochemical Pharmacology(1984)
Save reference to library·Related research1 reader
Effects of soman (pinacolyl methylphosphonofluoridate) on coronary blood flow and cardiac function in swine.
J E McKenzie, D M Scandling, N W Ahle, H J Bryant, R R Kyle, P H Abbrechtin Fundamental and applied toxicology official journal of the Society of Toxicology(1996)
Save reference to library·Related research2 readers
Effects of the acetylcholinesterase inhibitor pinacolyl methylphosphonofluoridate (soman) on selected endocrine, glucose, and catecholamine levels in fasted and fed rats.
H P Fletcher, S A Noble, G R Sprattoin Toxicology(1988)
Save reference to library·Related research1 reader
More related papers
Cite this document (BETA)
APA
BibTeX
Cell
Chicago
Harvard
MLA
Nature
Science
Choose a citation style from the tabs above.